Fas Pathway of Cell Death and B Cell Dysregulation in SLE
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چکیده
منابع مشابه
Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand.
Immune function in SLE is paradoxically characterized by active T cell help for autoantibody production, along with impaired T cell proliferative and cytokine responses in vitro. To reconcile these observations, we investigated the possibility that the accelerated spontaneous cell death of SLE lymphocytes in vitro is caused by an activation-induced cell death process initiated in vivo. 27 SLE p...
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Background and purpose: Apoptosis is a physiological mechanism of programmed cell death that dysregulation in this process may lead to carcinogenesis. Functional gene polymorphism in Fas can alter transcriptional activities and thus change the risks of cancer. A to G substitution in Fas -670 promoter region disrupts the binding site of STAT1 transcription factor. This study aimed to assess the ...
متن کاملNew Perspectives on the Role of Hyperglycemia, Free Fatty Acid and Oxidative Stress in B-Cell Apoptosis
Apoptosis is a complex network of biochemical and molecular pathway with fine regulatory mechanisms that control the death event during several pathological situations in multi cellular organisms. It is the part of normal development that occurs in a variety of diseases and is known as aberrant apoptosis. Pancreatic β cell apoptosis is also a pathological feature which is common in both type 1 ...
متن کامل(lpr is for lymphoproliferation) spontaneously develop a precocious SLE-like autoimmune disease with vasculitis and immune-complex glomerulonephritis and nonmalig-
Dr. Philippe Musette Institut de Recherche sur la Peau Hôpital Saint-Louis 1, avenue Vellefaux F–75475 Paris Cedex 10 (France) Systemic lupus erythematosus (SLE) is characterized by generalized autoimmunity towards many organs and involves B cell hyperactivity, autoantibody production and deposits of immune complexes in vital organs. Tolerance to antigens ceases at the onset of the disease, but...
متن کاملCoexpression of FAS and FAS-ligand in chronic pancreatitis: correlation with apoptosis.
Activation of the Fas receptor by Fas-ligand (FasL) results in apoptosis, and dysregulation of this pathway may contribute to abnormal cell proliferation and cell death. The aim of this study was to compare the expression of Fas and FasL in the normal pancreas and chronic pancreatitis (CP). By Northern blotting, Fas messenger RNA (mRNA) levels were increased in CP in comparison to the normal pa...
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تاریخ انتشار 2017